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Glutamate receptor AMPA type subunit GluA1 (GluA1)
- Target
- GluA1
- Molecular classification
- Receptor, Ion channel, Glutamate receptor, AMPA receptor
01
Overview
The Glutamate receptor AMPA type subunit GluA1 (GluA1), encoded by the GRIA1 gene, is a critical subunit of AMPA-type ionotropic glutamate receptors (AMPARs). AMPARs mediate fast excitatory synaptic transmission in the brain. GluA1 plays a crucial role in synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), through phosphorylation-dependent trafficking and conductance changes. Its dysregulation is implicated in cognitive disorders and neurodegenerative diseases.
- Other names
- GRIA1GluR1GLUR-AGLUA-01
02
Mechanism of action
Ligand-gated ion channel activation; phosphorylation-dependent regulation of trafficking and conductance
03
Biological functions
Synaptic transmissionLong-term potentiation (LTP)Long-term depression (LTD)Synaptic plasticityRegulation of membrane potential
04
Disease associations
Alzheimer’s diseaseCognitive disordersIntellectual disabilitiesNeurodegenerative disease
05
Safety considerations
Potential for excitotoxicity if dysregulatedComplex regulation via multiple phosphorylation sites makes therapeutic targeting challenging
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