Glutamate receptor-interacting protein 1 (GRIP1)

Glutamate receptor-interacting protein 1 (GRIP1) is a multi-PDZ domain scaffold protein that functions primarily by binding to and organizing transmembrane proteins, notably AMPA-type glutamate receptors, at synaptic sites in neurons[3][6][7]. It is critical in the targeting, stabilization, and trafficking of these receptors and contributes to synaptic plasticity and neural development[3][6]. GRIP1 also plays essential roles in non-neuronal tissues, such as the skin and kidneys, through its interaction with the FRAS1 and FREM2 proteins, helping form and stabilize basement membranes during embryonic development[1][5]. Mutations in GRIP1 are implicated in a minority of cases of Fraser syndrome, a rare congenital disorder with defects in organ and tissue morphogenesis[1][5]. GRIP1 itself is not a direct therapeutic target such as a receptor or enzyme but rather acts as a scaffold/adaptor; there are no known drugs targeting GRIP1 or using it as a biomarker[6][7].

Other names

GRIP1GRIP-1FRASRS3GRIPGlutamate receptor interacting protein 1