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Glutamate receptor ionotropic, NMDA 2B (NR2B)
- Target
- NR2B
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor
01
Overview
Glutamate receptor ionotropic, NMDA 2B (NR2B or GluN2B), is a subunit of the NMDA receptor, a ligand-gated ion channel crucial for excitatory neurotransmission. It forms a heterotetrameric complex with NR1 subunits, mediating synaptic plasticity, learning, memory, and brain development. Mutations in GRIN2B, encoding NR2B, are associated with various neurodevelopmental disorders. Activation requires glutamate and glycine/D-serine binding, as well as membrane depolarization to relieve Mg2+ block.
- Other names
- GluN2BNMDAR2BEpsilon-2NMDA receptor subtype 2b/subunit betaHNR3NR3N-methyl-D-aspartate receptor subtype 3
02
Mechanism of action
Ligand-gated cation channel activation requiring glutamate, glycine/D-serine binding and membrane depolarization.
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLong-term potentiation (LTP)Long-term depression (LTD)Neural pattern formationSignal transduction
04
Disease associations
Neurodevelopmental disordersIntellectual disabilityDevelopmental delayEpilepsy syndromesAutism spectrum disorderMovement disordersSchizophrenia risk factorsStroke
05
Safety considerations
Mutations lead to neurodevelopmental disorders.Excessive Ca2+ influx can lead to neuronal death after ischemic injury.
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