Glutamate receptor ionotropic, NMDA 2C subunit (GluN2C (also GRIN2C, based on gene symbol))

The Glutamate receptor ionotropic, NMDA 2C subunit (GluN2C/GRIN2C) is encoded by the GRIN2C gene and forms part of the heterotetrameric NMDA receptor complex in the brain[5][6]. These receptors are ligand-gated ion channels that mediate excitatory synaptic transmission by permitting calcium and sodium influx upon activation by glutamate and co-agonist glycine or D-serine[1][6]. The GluN2C subunit is critical for the receptor's ion selectivity, gating characteristics, and pharmacological profile. NMDA receptor dysfunctions have been linked to a variety of neurological and psychiatric diseases, making GluN2C a therapeutic target and focal point in drug development[3][5][6].

Other names

GRIN2C (gene name)GluN2C (protein name)N-methyl-D-aspartate receptor subunit 2C

NMDA receptor antagonists block glutamate binding or channel opening, inhibiting excitatory neurotransmission\nChannel blockers inhibit Ca²⁺ influx through the receptor channel