Glutamate receptor ionotropic, NMDA 3A (GRIN3A)

Glutamate receptor ionotropic, NMDA 3A (GRIN3A), also known as GluN3A, is a subunit of NMDA-type ionotropic glutamate receptors. NMDA receptors are ligand-gated cation channels crucial for excitatory neurotransmission and synaptic plasticity in the central nervous system. The GluN3A subunit assembles with other subunits (GluN1, GluN2) to form receptor complexes with altered properties, such as reduced calcium permeability and weaker magnesium block. It is involved in the refinement of synaptic connections during neural development and restricts dendritic spine maturation. GRIN3A variants are linked to neurological disorders including epilepsy and neuropsychiatric conditions. Currently, no drugs are approved that specifically target GluN3A; all clinically used NMDA receptor antagonists act more broadly[1][2][3][6].

Other names

Glutamate ionotropic receptor NMDA type subunit 3AGluN3ANMDAR3ANR3ANMDAR-Lglutamate [NMDA] receptor subunit 3AKIAA1973glutamate receptor ionotropic, NMDA 3AN-methyl-D-aspartate receptor subtype 3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3AmKIAA1973chi-1NR3

Antagonism or modulation of NMDA receptor ion channel activity; for drugs like ketamine, blockade of NMDA receptor-mediated excitatory neurotransmission[1][6].