Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate Receptor Ionotropic AMPA Subtype (AMPAR)
- Target
- AMPAR
- Molecular classification
- Ion channel, Receptor, Ligand-gated ion channel
01
Overview
The glutamate receptor ionotropic AMPA subtype (AMPAR) is a ligand-gated ion channel that mediates fast excitatory neurotransmission in the CNS. It is a tetramer composed of GluA1–GluA4 subunits. Upon activation by glutamate or agonists, the channel opens, allowing rapid influx of sodium ions, depolarizing postsynaptic neurons. Malfunction or dysregulation is implicated in neurological diseases, including epilepsy and neurodegeneration.
- Other names
- AMPA ReceptorQuisqualate Receptor
02
Mechanism of action
Cation channel opening upon agonist binding, leading to neuronal depolarization.
03
Biological functions
Fast excitatory neurotransmissionSynaptic plasticityLearningMemory formation
04
Disease associations
EpilepsyNeurodegenerative diseaseIschemia-induced neuronal damage (excitotoxicity)
05
Safety considerations
ExcitotoxicitySeizuresNeurological side effects
06
Interacting drugs
Glutamate
5 more in the full profile.
Beyond the preview
Go deeper on Glutamate Receptor Ionotropic AMPA Subtype (AMPAR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate Receptor Ionotropic AMPA Subtype (AMPAR).