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Glutamate Receptor Ionotropic AMPA Subtype Subunit GluA2 (GluA2)
- Target
- GluA2
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, AMPA receptor subunit
01
Overview
GluA2 (GRIA2 or GluR2) is a subunit of the AMPA-type ionotropic glutamate receptor, mediating fast excitatory neurotransmission in the CNS. GluA2's presence and RNA editing status (Q/R site) determine key properties like Ca²⁺ permeability and inward rectification. It also regulates AMPAR trafficking, a critical process for synaptic plasticity. Interactions involving the extracellular domain of GluA2 with N-cadherin regulate metabotropic glutamate receptor-dependent long-term depression. The structure of GluA2 has been solved, informing drug design targeting specific functional states or isoform compositions.
- Other names
- GRIA2GluR2
02
Mechanism of action
Agonist binding leading to ion channel opening and neuronal excitation; modulation of receptor activity via allosteric binding sites.
03
Biological functions
Fast excitatory neurotransmissionSynaptic plasticityRegulation of AMPAR traffickingRegulation of synapse strengthLearningMemory
04
Disease associations
Neurodegenerative diseasesEpilepsyIschemic strokeSchizophreniaAutism Spectrum DisorderOther
05
Safety considerations
ExcitotoxicitySeizuresPotential for off-target effects due to structural similarity with other glutamate receptors
06
Interacting drugs
AMPA
3 more in the full profile.
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