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Target intelligence / Profile preview
Glutamate Receptor Ionotropic Kainate Subtype (KAR)
- Target
- KAR
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor, Glutamate receptor
01
Overview
The glutamate receptor ionotropic kainate subtype (KARs) is a family of tetrameric ligand-gated cation channels activated by glutamate and kainic acid. These receptors mediate fast excitatory synaptic transmission in the CNS and modulate neurotransmitter release. They are composed of various combinations of five subunits: GluK1–GluK5. KARs are promising targets for pharmacotherapy in neurological diseases involving basal ganglia dysfunctions such as epilepsy or movement disorders.
- Other names
- Excitatory amino acid receptor 3EAA3GLUR5GLUR6GLUR7KA1KA2
02
Mechanism of action
Ligand-gated cation channel activation
03
Biological functions
Synaptic transmissionNeurotransmissionRegulation of neurotransmitter releaseModulation of neuronal excitability
04
Disease associations
EpilepsyMovement disordersNeurodegenerative disease
05
Interacting drugs
Kainic acid
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