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Target intelligence / Profile preview
Glutamate receptor ionotropic NMDA 3A (GluN3A)
- Target
- GluN3A
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor, Glutamate receptor, NMDA receptor subunit
01
Overview
Glutamate receptor ionotropic, NMDA 3A (GluN3A), is a subunit of the N-methyl-D-aspartate (NMDA) receptor, a ligand-gated ion channel mediating excitatory neurotransmission. Functional GluN1/GluN3A receptors are uniquely activated by glycine and play distinct roles in neuronal excitability and neural circuit function, especially during early brain development. Alterations in GRIN3A are implicated in neurodevelopmental disorders.
- Other names
- GRIN3AKIAA1973N-methyl-D-aspartate receptor subtype 3ANMDAR-LNMDAR3ANR3A
02
Mechanism of action
Glycine-gated ion channel activation, modulation of neuronal excitability
03
Biological functions
Excitatory neurotransmissionRegulation of neuronal excitabilityModulation of neural circuit functionGlycine-gated ion channel activity
04
Disease associations
Neurodevelopmental disordersNeurological disorders
05
Safety considerations
Potential for excitotoxicityComplex role in neurodevelopment
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