Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate Receptor Ionotropic NMDA Subtype (NMDAR)
- Target
- NMDAR
- Molecular classification
- Ion channel, Receptor, Ligand-gated ion channel, Ionotropic glutamate receptor
01
Overview
The NMDA receptor is a subtype of ionotropic glutamate receptors, which are ligand-gated ion channels mediating the majority of excitatory neurotransmission in the mammalian central nervous system. It requires co-binding of glutamate and glycine for activation and is characterized by voltage-dependent Mg²⁺ block and high Ca²⁺ permeability. It plays a crucial role in synaptic plasticity and is implicated in various neurological disorders.
- Other names
- NMDA ReceptorN-methyl-D-aspartate receptor
02
Mechanism of action
Ligand-gated ion channel activation/blockade
03
Biological functions
Synaptic plasticityLong-term potentiationLong-term depressionExcitatory neurotransmissionLearning and memorySignal transduction
04
Disease associations
EpilepsyNeurodegenerative diseaseAlzheimer's diseaseSchizophreniaIschemia-induced neuronal damageExcitotoxicityChronic pain syndromesCancer
05
Safety considerations
ExcitotoxicityNeuronal damageSide effects of antagonists
06
Interacting drugs
Glycine
5 more in the full profile.
Beyond the preview
Go deeper on Glutamate Receptor Ionotropic NMDA Subtype (NMDAR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate Receptor Ionotropic NMDA Subtype (NMDAR).