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Target intelligence / Profile preview
Glutamate Receptor Ionotropic NMDA Subunit (NMDAR)
- Target
- NMDAR
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
The NMDA receptor is an ionotropic glutamate receptor that plays a critical role in excitatory neurotransmission, synaptic plasticity, learning, and memory. It is a heterotetramer composed of GluN1 and GluN2/GluN3 subunits, and its activation requires the binding of both glutamate and glycine. The receptor is a nonselective cation channel permeable to Na+, K+, and Ca²⁺, and is uniquely blocked by Mg²⁺ ions in a voltage-dependent manner. Dysregulation of NMDA receptor activity is implicated in various neurological disorders.
- Other names
- N-methyl-D-aspartate receptorNMDA receptorGluN1GluN2AGluN2BGluN2CGluN2DGluN3AGluN3BNR1NR2ANR2BNR2CNR2DNR3ANR3B
02
Mechanism of action
Channel blocker
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLong-term potentiation (LTP)Long-term depression (LTD)LearningMemoryNeuronal developmentSynaptogenesisCalcium signaling
04
Disease associations
EpilepsySchizophreniaAlzheimer's diseaseNeurodegenerative diseaseIschemic brain injuryStrokeExcitotoxicity
05
Safety considerations
Excitotoxicity due to excessive Ca²⁺ influxPotential for drug-induced psychosis or cognitive impairment
06
Interacting drugs
Glutamate
2 more in the full profile.
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