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Target intelligence / Profile preview
Glutamate receptor ionotropic NMDA subunit 2C (GluN2C)
- Target
- GluN2C
- Molecular classification
- Ionotropic glutamate receptor, NMDA receptor subunit, Ligand-gated ion channel, Receptor
01
Overview
Glutamate receptor ionotropic NMDA subunit 2C (GRIN2C) is a protein that forms part of the N-methyl-D-aspartate (NMDA) receptor complex. The NMDA receptor is a subtype of ionotropic glutamate receptors, which are ligand-gated ion channels mediating excitatory neurotransmission in the central nervous system. GluN2C participates in synaptic plasticity processes such as learning and memory formation by contributing to long-term potentiation (LTP) and modulating excitatory postsynaptic currents. The pharmacological profile and function of NMDA receptors vary depending on the specific subunit composition, making GRIN2C a key modulator of neuronal excitability and synaptic transmission.
- Other names
- GRIN2CN-methyl-D-aspartate receptor subunit 2CGluN2C subunit
02
Mechanism of action
NMDA receptor agonist/antagonist (depending on the specific drug)
03
Biological functions
Calcium-permeable excitatory neurotransmissionSynaptic plasticityLearning and memoryRegulation of gene expressionIonotropic glutamate receptor signaling pathwayModulation/regulation of chemical synaptic transmissionRegulation of monoatomic cation transmembrane transport activity
04
Disease associations
Neurodevelopmental disordersNeurodegenerative diseasesCognitive impairment
05
Safety considerations
Potential for excitotoxicitySide effects associated with NMDA receptor modulation
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