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Glutamate receptor ionotropic NMDA subunit 2D (GluN2D)
- Target
- GluN2D
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, Glutamate receptor
01
Overview
Glutamate receptor ionotropic NMDA subunit 2D (GluN2D) is a subunit of the NMDA receptor, an ionotropic glutamate receptor that plays a critical role in excitatory neurotransmission, synaptic plasticity, learning, and memory. It forms heterotetrameric complexes with GluN1 subunits to create functional NMDA receptors. GluN2D contributes unique characteristics to the receptor complex. Mutations in the GRIN2D gene are associated with neurological disorders such as epileptic encephalopathies and intellectual disability.
- Other names
- EB11NMDAR2DNR2DEIEE46/DEE46
02
Mechanism of action
Ligand-gated ion channel activation/blockade; Allosteric modulation
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLearning and memoryLong-term potentiationCation channel activity
04
Disease associations
Epileptic encephalopathy (EIEE46/DEE46)Intellectual disabilitySchizophreniaNeurological disorders
05
Safety considerations
Potential for excitotoxicitySide effects of NMDA receptor antagonists
06
Interacting drugs
Memantine
6 more in the full profile.
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