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Glutamate receptor ionotropic NMDA subunit 3A (GRIN3A)
- Target
- GRIN3A
- Molecular classification
- Ion channel, Receptor, Ligand-gated ion channel, Ionotropic glutamate receptor
01
Overview
GRIN3A encodes the GluN3A subunit of the NMDA receptor, an ionotropic glutamate receptor. GluN3A-containing NMDARs modulate synaptic transmission by altering channel properties such as activation kinetics, deactivation rates, desensitization profiles, calcium permeability, and magnesium sensitivity. These receptors play critical roles in synaptic plasticity, learning, memory, and neuronal development. Unlike conventional NMDARs that require both glutamate and glycine for activation, receptors containing only NR1/GluN1 plus NR3/GluN3 are activated exclusively by glycine, making them functionally distinct from typical excitatory NMDARs. Overexpression of GluN3A has shown neuroprotective effects in animal models of cerebral ischemia.
- Other names
- GluN3ANR3A
02
Mechanism of action
Modulates NMDA receptor channel properties (activation kinetics, calcium permeability, etc.) by forming heterotetrameric receptor complexes with GluN1 and/or GluN2 subunits; glycine binding to GluN1/GluN3 heteromers.
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityNeuronal developmentSynapse formation
04
Disease associations
Ischemic strokeEpilepsySchizophreniaMood disordersNeurodevelopmental disordersNeuropsychiatric disorders
05
Safety considerations
Potential for excitotoxicity if receptor function is dysregulated.
06
Interacting drugs
Glycine
1 more in the full profile.
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