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Target intelligence / Profile preview
Glutamate Receptor Ionotropic NMDA Subunit 3B (GRIN3B)
- Target
- GRIN3B
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
Glutamate receptor ionotropic NMDA subunit 3B (GRIN3B), also known as GluN3B or NR3B, is a protein that forms part of the N-methyl-D-aspartate (NMDA) receptor complex. The inclusion of NR3/GluN3 reduces calcium influx through the channel, alters channel kinetics, and changes sensitivity to agonists like glycine and glutamate. GRIN3B is found primarily in motor neurons and plays a role in synaptic plasticity, memory formation, learning processes, neural development, excitatory neurotransmission, and neuroprotection/neurotoxicity balance. Variants in *GRIN* genes have been associated with neurological disorders including intellectual disability and epilepsy.
- Other names
- GluN3BNR3B
02
Mechanism of action
Ligand-gated ion channel activity; modulation of NMDA receptor function
03
Biological functions
Regulation of synaptic transmissionProtein insertion into membraneRegulation/modulation of Ca²⁺ influxExcitatory neurotransmissionModulation of calcium signaling into mitochondria
04
Disease associations
Neurological disordersIntellectual disabilityEpilepsy
05
Safety considerations
Potential for neurotoxicity if dysregulatedChallenges in selectively targeting GRIN3B over other NMDA receptor subunits
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