Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate Receptor NMDA Subtype (NMDAR)
- Target
- NMDAR
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, Glutamate receptor
01
Overview
The N-methyl-D-aspartate (NMDA) receptor is a subtype of glutamate receptor and functions as a ligand-gated ion channel in the central nervous system. It plays a critical role in excitatory neurotransmission, synaptic plasticity, learning, and memory formation. The NMDA receptor is unique among ionotropic glutamate receptors for its high calcium permeability and voltage-dependent activation due to magnesium block.
- Other names
- N-methyl-D-aspartate ReceptorNMDA ReceptorN-Methyl-D-Aspartate ReceptoriGluR
02
Mechanism of action
Ligand binding and membrane depolarization open the ion channel, allowing influx of Ca²⁺ and Na⁺ ions, and efflux of K⁺ ions. Antagonists block the channel pore, preventing ion flow.
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLong-term potentiationLong-term depressionLearningMemory formationIon transportSignal transduction
04
Disease associations
Neurodegenerative diseaseAlzheimer's diseaseStrokeEpilepsyExcitotoxicityNeurological disordersPsychiatric disorders
05
Safety considerations
Excitotoxicity due to excessive Ca²⁺ influxPotential for neurotoxicity with certain antagonistsPsychomimetic effects with some antagonists
06
Interacting drugs
L-glutamate
7 more in the full profile.
Beyond the preview
Go deeper on Glutamate Receptor NMDA Subtype (NMDAR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate Receptor NMDA Subtype (NMDAR).