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Glutamate-rich protein 5 (ERICH5)
- Target
- ERICH5
- Molecular classification
- Other (Protein with domain of unknown function DUF4573)
01
Overview
Glutamate-rich protein 5 (ERICH5) is encoded by the ERICH5 gene on human chromosome 8q22.2 and contains three exons[2][7]. The protein is predicted to localize to the nucleus, contains a conserved domain of unknown function (DUF4573), and has motifs linked to APC/C binding and nuclear cell checkpoint processes[2]. ERICH5 exists in two isoforms, interacts with several nuclear proteins, and is expressed most highly in the fetal liver, adult liver, pancreas, and retina[2][1][5][6]. It shows increased expression in Alcoholic Hepatitis but no substantial evidence for a therapeutic target role or direct involvement in major human diseases[2][5]. No drugs, biomarkers, or safety concerns have been identified in relation to this gene/protein to date.
- Other names
- ERICH5C8orf47Glutamate-rich protein 5FLJ39553
02
Biological functions
Protein bindingPredicted involvement in cell checkpoint pathways via FHA motifPutative APC/C (anaphase-promoting complex) binding (suggesting a role in cell cycle regulation)
03
Disease associations
Increased expression observed in Alcoholic HepatitisNo established direct roles in cancer, inflammation, neurodegenerative disease, cardiovascular disease, infection, or other major categories
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