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Glutamate Transporter 1 (GLT-1)
- Target
- GLT-1
- Molecular classification
- Solute Carrier Family SLC1, Transporter
01
Overview
Glutamate transporter 1 (GLT-1), also known as Excitatory Amino Acid Transporter 2 (EAAT2), is a high-affinity glutamate transporter predominantly found in astrocytes within the central nervous system. It plays a critical role in regulating extracellular glutamate concentrations by transporting glutamate from the synaptic cleft, thereby preventing excitotoxicity. GLT-1 dysfunction is implicated in several neurological disorders, making it a therapeutic target for neuroprotection.
- Other names
- Excitatory Amino Acid Transporter 2EAAT2SLC1A2
02
Mechanism of action
Upregulation of GLT-1 expression/activity (Ceftriaxone); Noncompetitive inhibition of conformational changes (UCPH101)
03
Biological functions
L-glutamate uptakeNeurotransmitter clearanceRegulation of extracellular glutamate concentrationMaintenance of excitatory neurotransmissionPrevention of excitotoxicity
04
Disease associations
EpilepsyStrokeAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)Movement disordersNeurodegenerative disease
05
Safety considerations
Dysfunction leads to excitotoxicityImpaired glutamate clearance
06
Interacting drugs
Ceftriaxone
1 more in the full profile.
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