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Target intelligence / Profile preview
Glutamatergic Receptor
- Molecular classification
- Receptor, Ionotropic receptor, Metabotropic receptor, Ligand-gated ion channel, G protein-coupled receptor
01
Overview
Glutamatergic receptors, also known as glutamate receptors, are a family of cell surface proteins that mediate the effects of the neurotransmitter glutamate—the primary excitatory neurotransmitter in the central nervous system (CNS). These receptors are essential for fast excitatory synaptic transmission, synaptic plasticity, neuronal development, learning, memory formation, and overall neuronal communication. They are divided into two main classes: Ionotropic (NMDA, AMPA, Kainate) which are ligand-gated ion channels, and Metabotropic (mGluR1–mGluR8) which are G-protein-coupled receptors.
- Other names
- Glutamate Receptor
02
Mechanism of action
Ligand binding leading to ion channel opening (ionotropic) or G-protein activation (metabotropic)
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLearningMemoryNeuronal developmentNeuronal differentiationRegulation of gene expressionSignal transduction
04
Disease associations
StrokeIschemiaNeurodegenerative diseaseExcitotoxicity
05
Safety considerations
Excitotoxicity leading to neurodegeneration
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