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Glutamatergic System

Molecular classification: Neurotransmitter System

Overview

The glutamate system refers to the network of molecules, receptors, and pathways involving glutamate, the most abundant excitatory neurotransmitter in the brain and central nervous system. It plays a critical role in neural communication, learning, memory formation, synaptic plasticity, and overall brain function. Dysregulation or overactivation (excitotoxicity) can lead to neuronal damage implicated in various neurological disorders.

Other names: Glutamatergic Neurotransmission

Biological functions

Excitatory NeurotransmissionLearning & MemoryNeural PlasticityPain SensitivityTaste Perception

Disease associations

EpilepsyStroke-induced injuryAmyotrophic lateral sclerosis (ALS)Alzheimer's diseaseSchizophreniaDepressionChronic pain syndromes

Safety considerations

Excitotoxicity

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