Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamic Acid Decarboxylase (GAD)
- Target
- GAD
- Molecular classification
- Enzyme, Decarboxylase
01
Overview
Glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to produce gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system, and carbon dioxide. There are two main isoforms, GAD65 and GAD67. GAD is a key autoantigen in type I diabetes and is also implicated in several neurological disorders.
- Other names
- GAD65GAD67
02
Mechanism of action
N/A
03
Biological functions
NeurotransmissionGABA synthesisRegulation of neuronal excitabilityCell signaling
04
Disease associations
Type I Diabetes MellitusStiff-person syndromeChronic cerebellar ataxiaDrug-resistant epilepsyMyoclonusAutoimmune disordersNeurological Disorders
05
Safety considerations
AutoimmunityPotential for GABAergic dysfunction
06
Biomarkers
Anti-GAD antibodies
Beyond the preview
Go deeper on Glutamic Acid Decarboxylase (GAD).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamic Acid Decarboxylase (GAD).