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Target intelligence / Profile preview
Glutamic Acid Decarboxylase 2 (GAD65)
- Target
- GAD65
- Molecular classification
- Enzyme, Lyase
01
Overview
Glutamic acid decarboxylase 2 (GAD2), also known as GAD65, is an enzyme that catalyzes the conversion of L-glutamic acid to gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system. It is a key autoantigen in type 1 diabetes and implicated in other autoimmune diseases.
- Other names
- Glutamate decarboxylase 65 kDa isoformGAD2
02
Mechanism of action
Catalyzes the conversion of L-glutamic acid to gamma-aminobutyric acid (GABA)
03
Biological functions
Neurotransmitter synthesisGABA productionSynaptic transmission
04
Disease associations
Type 1 Diabetes MellitusStiff-person SyndromeAutoimmune Diseases
05
Safety considerations
Potential for off-target effects in autoimmune therapiesDisruption of GABAergic neurotransmission
06
Biomarkers
GAD65 autoantibodies (T1DM diagnostic marker)
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