Target intelligence / Profile preview

Glutaminase C (GAC)

Target: GAC
Molecular classification: Enzyme, Hydrolase

Overview

Glutaminase C (GAC) is a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to glutamate, a critical step in glutamine metabolism. As a splice variant of the GLS1 gene, GAC plays a vital role in supplying intermediates for the tricarboxylic acid (TCA) cycle, particularly in rapidly proliferating cells like cancer cells. GAC's upregulation in various tumors makes it an attractive target for anticancer drug development.

Mechanism of action

Inhibition of glutamine hydrolysis

Biological functions

Anaplerosis via TCA cycle supportCancer cell proliferationMicroglial activationGlutamine metabolism

Disease associations

CancerNeurodegenerative diseaseNeuroinflammationGliomas

Safety considerations

Potential for off-target effects on other glutaminase isoformsDisruption of normal glutamine metabolism

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