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Target intelligence / Profile preview
Glutamine–5-phosphoribosylpyrophosphate Amidotransferase (GPAT)
- Target
- GPAT
- Molecular classification
- Enzyme, Short-chain dehydrogenases/reductases
01
Overview
Glutamine–5-phosphoribosylpyrophosphate amidotransferase (GPAT) is a key enzyme in the de novo purine biosynthesis pathway. It catalyzes the first committed step: the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine into 5-phosphoribosyl-1-amine (PRA), pyrophosphate, and glutamate. GPAT is tightly regulated and a potential therapeutic target, particularly in cancer.
- Other names
- ATaseAmidophosphoribosyltransferase
02
Mechanism of action
Covalent modification of active site cysteine, inhibiting glutamine binding and glutaminolysis.
03
Biological functions
Purine biosynthesisNucleotide metabolismCell proliferationAmino acid metabolism
04
Disease associations
Mature B-cell lymphomaTransplant rejectionCancer
05
Safety considerations
Potential for off-target effects due to broad role in nucleotide synthesis.Inhibition can impact normal cell function alongside cancerous cells.
06
Interacting drugs
DON (6-diazo‑5‑oxo L-norleucine)
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