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Target intelligence / Profile preview
Glutamine-5-phosphoribosylpyrophosphate Amidotransferase (GPAT)
- Target
- GPAT
- Molecular classification
- Enzyme, Short-chain dehydrogenases/reductases
01
Overview
Glutamine-5-phosphoribosylpyrophosphate amidotransferase (GPAT) is a key enzyme in the de novo purine biosynthesis pathway. It catalyzes the first committed step of this pathway: the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine into 5-phosphoribosyl-1-amine (PRA). GPAT is allosterically regulated by AMP and GMP, ensuring balanced purine nucleotide synthesis. It is considered an attractive target for anticancer drug development.
- Other names
- AmidophosphoribosyltransferaseATase
02
Mechanism of action
Inhibition of glutaminase activity, leading to disruption of purine biosynthesis
03
Biological functions
Purine biosynthesisAmino acid metabolism
04
Disease associations
CancerTransplant rejection
05
Safety considerations
Potential for broad effects on rapidly dividing cells due to disruption of purine biosynthesis.
06
Interacting drugs
DON (6-diazo-5 oxo-L-norleucine)
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