Glutamine amidotransferase class 1 domain containing 1 (GATD1)

Glutamine amidotransferase class 1 domain containing 1 (GATD1) is a protein-coding gene and a member of the peptidase C56 family. It is a component of the FERRY complex, a five-subunit endosomal Rab5 and RNA/ribosome intermediary complex, which interacts directly with mRNAs and RAB5A. This protein is involved in facilitating the localization and distribution of specific mRNAs, most likely by mediating their endosomal transport. GATD1 is predicted to possess glyoxalase III activity, catalyzing methylglyoxal metabolism to D-lactate via S-lactoyl-glutathione, and appears to function in cellular mRNA and ribosome recruitment to early endosomes through direct mRNA interaction. There are no current reports of direct disease association, therapeutic targeting, or pharmacological modulation of GATD1 in the literature[4][1].

Other names

Glutamine amidotransferase-like class 1 domain-containing protein 1GATD1FERRY5PDDC1Fy-5FLJ34283Ferry endosomal RAB5 effector complex subunit 5Parkinson disease 7 domain-containing protein 1

Not applicable; no drugs known to target this molecule