Glutamine metabolic pathway (null)

The glutamine metabolic pathway encompasses the cellular uptake of glutamine, primarily via transporters such as SLC1A5/ASCT2, and its subsequent catabolism. Glutamine is converted to glutamate by glutaminase (GLS); from there, glutamate feeds into various biosynthetic processes and energy-producing pathways, notably the tricarboxylic acid (TCA) cycle via conversion to α-ketoglutarate. Glutamine also donates nitrogen for nucleotide and amino acid synthesis and supports redox balance through glutathione production. Enhanced glutamine metabolism is a hallmark of many cancers, contributing to tumor growth, survival, and resistance, making components of this pathway—such as glutaminase and glutamine transporters—therapeutic targets under study in oncology and other disease settings.

Other names

Glutamine metabolismGlutaminolysis

Inhibition of glutaminase (GLS) to reduce glutamine breakdown; Blockade of glutamine transporters (SLC1A5/ASCT2, SLC7A11) to prevent glutamine uptake; Disruption of redox homeostasis (via GSH depletion); Induction of ferroptosis (iron-dependent cell death via redox imbalance)