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Target intelligence / Profile preview
Amidophosphoribosyltransferase (ATase)
- Target
- ATase
- Molecular classification
- Enzyme, Transferase, Amidotransferase
01
Overview
Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is a key enzyme in the de novo purine biosynthesis pathway. It catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine into 5-phosphoribosyl-1-amine (PRA). This reaction represents the first committed step in purine nucleotide synthesis and is essential for cell proliferation and DNA/RNA production. It is a potential target for anti-cancer and anti-infective therapies.
- Other names
- GPATGlutamine phosphoribosylpyrophosphate amidotransferasePhosphoribosylpyrophosphate amidotransferasePurF gene product
02
Mechanism of action
Inhibition of de novo purine synthesis
03
Biological functions
CatalysisPurine nucleotide synthesisDe novo IMP biosynthetic processGlutamine metabolic processPurine metabolic processPyrimidine metabolic processNucleobase metabolic processNucleotide metabolic processes
04
Disease associations
CancerInfection
05
Safety considerations
Potential for broad toxicity due to essential role in cell proliferation
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