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Target intelligence / Profile preview
Glutamine PRPP amidotransferase (GPAT)
- Target
- GPAT
- Molecular classification
- Enzyme, Transferase
01
Overview
Glutamine PRPP amidotransferase (GPAT) is a key regulatory enzyme in the de novo purine biosynthesis pathway. It catalyzes the committed step, converting 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine to 5-phosphoribosylamine (PRA), the first unique precursor to purines. GPAT is a target for therapeutic intervention in diseases such as cancer and gout, where purine metabolism is dysregulated.
- Other names
- AmidophosphoribosyltransferaseGlutamine phosphoribosylpyrophosphate amidotransferasePRA synthasePP-ribose-P amidotransferase
02
Mechanism of action
Inhibition of purine synthesis
03
Biological functions
Purine nucleotide biosynthesisRegulation of purine metabolism
04
Disease associations
CancerGoutLesch-Nyhan syndrome (indirectly)
05
Safety considerations
Potential for immunosuppression if inhibited excessivelyDrug resistance
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