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Glutamine Transporter
- Molecular classification
- Transporter, Solute Carrier (SLC), SLC1 family, SLC6 family, SLC7 family, SLC38 family
01
Overview
Glutamine transporters are membrane proteins that facilitate the movement of glutamine across cellular membranes. They belong to several solute carrier (SLC) gene families, including SLC1, SLC6, SLC7 and SLC38. These transporters play crucial roles in nutrient absorption, reabsorption, neurotransmitter cycling, and metabolic regulation. ASCT2/SLC1A5 is a major glutamine transporter, particularly in cancer cells, and its inhibition is explored as a therapeutic strategy. They utilize Na+-dependent symport or antiport mechanisms.
- Other names
- SLC1A5ASCT2Sodium-dependent Alanine Serine Cysteine Transporter 2SNAT1SLC38A1SNAT2SLC38A2LAT-type transporters
02
Mechanism of action
Inhibition of glutamine transport, impacting mTORC signaling
03
Biological functions
Nutrient absorptionNutrient reabsorptionNeurotransmitter cyclingAmino acid transportMetabolic regulationmTORC1 signaling pathway regulation
04
Disease associations
CancerNeurological disorders (related to neurotransmitter imbalance)
05
Safety considerations
Selectivity challenges due to overlapping substrate profiles among different transporter subtypes.
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