Target intelligence / Profile preview

Glutaminolysis Pathway (None)

Target: None
Molecular classification: Metabolic Pathway, Biochemical Pathway

Overview

Glutaminolysis is a metabolic pathway that catabolizes the amino acid glutamine to generate energy and provide biosynthetic precursors for cell growth and proliferation. This pathway is especially important in rapidly dividing cells, such as cancer cells, immune cells, and certain kidney tissues. It serves as a key anaplerotic process, replenishing intermediates of the tricarboxylic acid (TCA) cycle via α-ketoglutarate production. Therapeutic targeting of this pathway is being explored, primarily in cancer.

Mechanism of action

Inhibition of glutamine transporters and enzymes involved in glutamine metabolism.

Biological functions

Energy generationBiosynthesis precursor supplyRedox balanceAnaplerotic processRegulation of cell growth and metabolism

Disease associations

Cancer metabolism ("glutamine addiction")Immune function modulationKidney diseaseMetabolic stress

Safety considerations

Potential for off-target effects due to the widespread role of glutamine metabolism in normal tissues.Development of resistance to glutaminolysis inhibitors.

Interacting drugs

benzylserine

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