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Glutaminyl-peptide Cyclotransferase
- Molecular classification
- Enzyme
01
Overview
Glutaminyl-peptide cyclotransferase (QPCT) is a zinc-dependent enzyme that catalyzes the intramolecular cyclization of N-terminal glutamine and glutamic acid residues in peptides to form pyroglutamate. This post-translational modification is crucial for the maturation and function of various peptide hormones and secretory proteins. Its dysregulation links it to neurodegenerative diseases like Alzheimer’s disease due to its role in amyloid plaque formation. It serves both physiological roles (hormone maturation) and pathological roles (tumor progression/inflammation).
- Other names
- Glutaminyl cyclaseQPCTGlutaminyl-tRNA cyclotransferaseGlutaminyl-transfer ribonucleate cyclotransferase
02
Mechanism of action
Inhibition of glutaminyl-peptide cyclotransferase activity to reduce pyroglutamate formation.
03
Biological functions
Maturation of peptide hormonesStabilization of peptide hormonesProtection from proteolysisPost-translational modification
04
Disease associations
Alzheimer’s diseaseCancerInflammationNeurodegenerative disease
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