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Glutamyl Aminopeptidase
- Molecular classification
- Enzyme, Metalloprotease, M1 family peptidase, Type II integral membrane protein
01
Overview
Glutamyl aminopeptidase (ENPEP), also known as Aminopeptidase A or CD249, is a zinc-dependent, membrane-bound metalloprotease that specifically removes N-terminal glutamic acid and aspartic acid residues from peptides and proteins. It plays a crucial role in the renin-angiotensin system by converting angiotensin II to angiotensin III, thereby influencing blood pressure regulation and vascular function. ENPEP is highly expressed in the small intestine and kidney, and its activity is modulated by calcium ions. It has been implicated in hypertension, atrial fibrillation, and cancer progression.
- Other names
- Aminopeptidase AAspartate aminopeptidaseAngiotensinase AGlutamyl peptidaseCa2+-activated glutamate aminopeptidaseMembrane aminopeptidase IIAntigen BP-1/6C3 (mouse)L-aspartate aminopeptidaseAngiotensinase A2CD249
02
Mechanism of action
Inhibition of N-terminal glutamic acid and aspartic acid cleavage from peptides and proteins.
03
Biological functions
Blood pressure regulationAngiotensin metabolismAngiogenesis
04
Disease associations
HypertensionAtrial fibrillationCancer progression
05
Interacting drugs
Puromycin
1 more in the full profile.
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