Glutaredoxin-like protein C5orf63 (C5orf63)

Glutaredoxin-like protein C5orf63 is a human mitochondrial protein encoded by the C5orf63 gene, located on chromosome 5[1][5][7]. It shares structural similarities with glutaredoxins, possessing domains consistent with oxidoreductase and thioredoxin-like activity, and is classified in protein families such as the glutaredoxin-like (IPR008554) and thioredoxin-like superfamilies (IPR036249)[10]. While canonical glutaredoxins catalyze reversible protein glutathionylation to maintain cellular redox homeostasis, the specific biological function of C5orf63 in humans remains uncharacterized; sequence analyses suggest a possible role in redox regulation or iron-sulfur cluster assembly, as seen in related family members[2][5][10]. There are no validated therapeutic drugs, biomarkers, or disease roles currently associated with C5orf63. It frequently appears in experimental contexts and databases under aliases such as YDR286C and FLJ44606, but its clinical relevance remains undetermined. C5orf63 interacts in protein networks with other mitochondrial and redox-related proteins, though no direct pharmacological interaction is documented[6][9].

Other names

Chromosome 5 open reading frame 63YDR286CFLJ44606Glutaredoxin-like protein YDR286C homolog

None reported for this target