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Target intelligence / Profile preview
Glutathione Peroxidase (GPx)
- Target
- GPx
- Molecular classification
- Enzyme, Peroxidase, Selenoprotein
01
Overview
Glutathione peroxidase (GPx) is a family of enzymes with peroxidase activity, protecting cells from oxidative damage by reducing hydrogen peroxide and organic hydroperoxides. It plays a critical role in antioxidant defense and redox signaling.
- Other names
- GPx1GPx2GPx3GPx4GPx5GPx6GPx7GPx8
02
Mechanism of action
Catalyzes the reduction of hydrogen peroxide and organic hydroperoxides using glutathione as a substrate, preventing oxidative damage.
03
Biological functions
Antioxidant defenseReduction of hydrogen peroxideReduction of lipid hydroperoxidesRedox signaling regulationCellular protection from oxidative damage
04
Disease associations
Cardiovascular diseasesCancerInflammationOxidative stress related diseases
05
Safety considerations
Selenium toxicity if selenium-containing isoforms are upregulated excessively by pharmacological intervention.Knockout models show increased sensitivity to oxidative stress
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