Target intelligence / Profile preview

Glutathione Peroxidase (GPx)

Target: GPx
Molecular classification: Enzyme, Peroxidase, Selenoprotein

Overview

Glutathione peroxidase (GPx) is a family of enzymes with peroxidase activity, protecting cells from oxidative damage by reducing hydrogen peroxide and organic hydroperoxides. It plays a critical role in antioxidant defense and redox signaling.

Other names: GPx1GPx2GPx3GPx4GPx5GPx6GPx7GPx8

Mechanism of action

Catalyzes the reduction of hydrogen peroxide and organic hydroperoxides using glutathione as a substrate, preventing oxidative damage.

Biological functions

Antioxidant defenseReduction of hydrogen peroxideReduction of lipid hydroperoxidesRedox signaling regulationCellular protection from oxidative damage

Disease associations

Cardiovascular diseasesCancerInflammationOxidative stress related diseases

Safety considerations

Selenium toxicity if selenium-containing isoforms are upregulated excessively by pharmacological intervention.Knockout models show increased sensitivity to oxidative stress

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