Glutathione peroxidase 3 (GPX3)

Glutathione peroxidase 3 is a selenium-containing enzyme primarily synthesized in renal proximal tubular cells and secreted into plasma, where it catalyzes the reduction of hydrogen peroxide and organic hydroperoxides using glutathione as a substrate[1][2][5][6][7]. It is distinguished from other glutathione peroxidases by its extracellular location and tetrameric structure, and it plays a key role in protecting the extracellular environment and various tissues from ROS-induced oxidative stress, supporting cellular health and defending against inflammation and degenerative processes, with clear implications for human disease[1][5][7].

Other names

plasma glutathione peroxidaseextracellular glutathione peroxidaseeGPXGPX-P

Drugs or interventions that increase GPX3 activity (such as selenium or antioxidant therapies) act by boosting its enzymatic reduction of hydrogen peroxide and other peroxides, thereby reducing oxidative tissue injury.