Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutathione reductase
- Molecular classification
- Enzyme, Flavoprotein
01
Overview
Glutathione reductase is a ubiquitous, homodimeric flavoprotein enzyme that plays a central role in cellular redox homeostasis by catalyzing the NADPH-dependent reduction of oxidized glutathione disulfide (GSSG) to its reduced form, glutathione (GSH). This reaction is essential for maintaining high intracellular levels of GSH, one of the most abundant and important cellular antioxidants.
02
Mechanism of action
Inhibition of glutathione reductase activity to modulate cellular redox state.
03
Biological functions
Redox homeostasisAntioxidant defenseDrug metabolismDetoxification
04
Disease associations
Neurodegenerative diseaseCancerAgingMetabolic disordersOxidative stress-related diseases
05
Safety considerations
Potential for disruption of redox balance if inhibited excessively.
Beyond the preview
Go deeper on Glutathione reductase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutathione reductase.