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Glutathione reductase

Molecular classification: Enzyme, Flavoprotein

Overview

Glutathione reductase is a ubiquitous, homodimeric flavoprotein enzyme that plays a central role in cellular redox homeostasis by catalyzing the NADPH-dependent reduction of oxidized glutathione disulfide (GSSG) to its reduced form, glutathione (GSH). This reaction is essential for maintaining high intracellular levels of GSH, one of the most abundant and important cellular antioxidants.

Mechanism of action

Inhibition of glutathione reductase activity to modulate cellular redox state.

Biological functions

Redox homeostasisAntioxidant defenseDrug metabolismDetoxification

Disease associations

Neurodegenerative diseaseCancerAgingMetabolic disordersOxidative stress-related diseases

Safety considerations

Potential for disruption of redox balance if inhibited excessively.

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