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Target intelligence / Profile preview
Glutathione S-transferase (GST)
- Target
- GST
- Molecular classification
- Enzyme, Transferase, Phase II metabolic enzyme, Detoxification enzyme
01
Overview
Glutathione S-transferases (GSTs) are a family of enzymes involved in detoxification and cellular protection against oxidative stress. They catalyze the conjugation of glutathione (GSH) to various electrophilic compounds, facilitating their removal from the cell. GSTs also possess peroxidase and isomerase activities and can modulate signaling pathways. Certain GST isoforms, particularly GSTP, are implicated in cancer development and chemoresistance. They are considered important targets for cancer therapy and other diseases involving oxidative stress.
- Other names
- LigandinGSTs
02
Mechanism of action
Catalyzes the conjugation of glutathione to electrophilic compounds, promoting detoxification and excretion; inhibits JNK activity.
03
Biological functions
DetoxificationGlutathione conjugationPeroxidase activityIsomerase activityAntioxidant activityRegulation of kinase activityLigand bindingStress response
04
Disease associations
CancerChemotherapeutic resistanceOxidative stress
05
Safety considerations
Overexpression can contribute to chemoresistance in cancer.
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