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Target intelligence / Profile preview
Glutathione S-transferase Mu 1 (GSTM1)
- Target
- GSTM1
- Molecular classification
- Enzyme, Glutathione S-transferase, Phase II Detoxification Enzyme
01
Overview
Glutathione S-transferase Mu 1 (GSTM1) is a member of the glutathione S-transferase (GST) superfamily, specifically belonging to the mu class. GSTs are phase II detoxification enzymes that catalyze the conjugation of reduced glutathione to a wide variety of electrophilic and hydrophobic compounds, facilitating their detoxification and excretion. Genetic variations, particularly null mutations, significantly impact individual susceptibility to toxins and disease.
- Other names
- GSTM1GST1GSTM1-1GTH4GTM1H-BMU
02
Mechanism of action
Catalyzes the conjugation of reduced glutathione (GSH) to electrophilic compounds, facilitating their detoxification and excretion.
03
Biological functions
DetoxificationConjugation of GSH to electrophilesNeutralization of reactive oxygen species (ROS)Metabolism of prostaglandins
04
Disease associations
CancerHypertensionChronic kidney disease
05
Safety considerations
Genetic polymorphisms (e.g., null genotype) can affect drug efficacy and toxicity.GSTM1 deficiency increases susceptibility to carcinogens and environmental toxins.
06
Biomarkers
GSTM1 genotype (null vs. present)GSTM1 expression levels
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