Glutathione S-transferase mu 2 pseudogene 1 (GSTM2P1)

Glutathione S-transferase mu 2 pseudogene 1 (GSTM2P1) is a human pseudogene related to the glutathione S-transferase mu family, which includes functional enzymes involved in detoxification of xenobiotics and reactive oxygen species through conjugation with glutathione[6]. Unlike its functional counterparts such as GSTM1 or GSTM2, GSTM2P1 does not code for a functional protein product and is typically not transcribed or translated. There is no evidence supporting a role for GSTM2P1 as a therapeutic target, nor is it involved in any known drug interactions or disease mechanisms. Key Notes: - This gene is **distinct** from *GSTM2* (Glutathione S-transferase mu 2), which is the protein-coding enzyme with established detoxification and possibly cancer risk modifying roles[6]. - Pseudogenes like GSTM2P1 generally do not have direct functional, disease, or therapeutic relevance, although emerging research explores regulatory functions or RNA-level effects for some pseudogenes; no such evidence is established for GSTM2P1 at this time. - Therapeutic and disease relevance for **glutathione S-transferase** family members generally applies to *protein-coding genes* such as GSTP1, GSTM1, and GSTM2, but not to this pseudogene[1][3][4][6].

Other names

GST mu 2 pseudogene 1GSTM2 pseudogene 1