Glutathione S-transferase mu 3 (GSTM3)

Glutathione S-transferase mu 3 (GSTM3) is a cytosolic phase II detoxification enzyme of the glutathione S-transferase (GST) superfamily (mu class), mainly functioning to catalyze the conjugation of reduced glutathione to a broad spectrum of endogenous and exogenous electrophilic compounds, including carcinogens, drugs, and environmental toxins. GSTM3 helps protect cells from oxidative and chemical stress and is expressed in various tissues (notably brain, liver, and testis). The gene is polymorphic, and these genetic variants can alter individual susceptibility to environmental toxins and carcinogens and modify drug response and toxicity, especially in the context of chemotherapy. Deregulation of GSTM3 is associated with various cancers and their progression, as well as variability in prognosis and therapeutic outcomes. In cancer biology, GSTM3 modulates processes such as ferroptosis and is being explored as a therapeutic and prognostic biomarker, particularly in treatment-resistant malignancies.

Other names

GSTM3GST5hGSTM3-3GST class-mu 3GSTM3-3GSTM3TV2GSTBGTM3S-(hydroxyalkyl)glutathione lyase M3brain GSTbrain type mu-glutathione S-transferaseepididymis secretory sperm binding proteinglutathione S-alkyltransferase M3glutathione S-aralkyltransferase M3glutathione S-aryltransferase M3

Glutathione conjugation: catalyzes the conjugation of glutathione to electrophilic compounds for detoxification; Modulation of oxidative stress and drug metabolism; Influences ferroptosis response in certain resistant cancers, which can be targeted through combination with ferroptosis-inducing drugs and radiotherapy.