Glutathione S-transferase Mu 4 (GSTM4)

Glutathione S-transferase Mu 4 (GSTM4) is a cytosolic enzyme of the mu class, encoded by the GSTM4 gene located on chromosome 1p13.3[1][3][8]. It catalyzes the conjugation of reduced glutathione to a diverse array of endogenous and exogenous electrophilic compounds, including drugs, carcinogens, and products of oxidative stress, facilitating their detoxification[1][3][4][5]. GSTM4 plays important roles in cellular protection, drug metabolism, and regulation of inflammatory mediators such as leukotriene C4, which may influence susceptibility and outcomes in diseases like cancer and inflammation[1][3][4][5][8]. Its gene displays polymorphism, leading to individual differences in toxin and drug metabolism. GSTM4 interacts with multiple drugs and is implicated in chemoresistance and differential drug responses[1][3][5].

Other names

GST class-mu 4GST-Mu2GSTM4-4Leukotriene C4 synthase GSTM4GTM4S-(hydroxyalkyl)glutathione lyase M4glutathione S-alkyltransferase M4glutathione S-aralkyltransferase M4glutathione S-aryltransferase M4glutathione S-transferase M4testis tissue sperm-binding protein Li 60n

Conjugates reduced glutathione to hydrophobic electrophiles, facilitating their excretion and detoxification[1][3][4][5]\nInhibition of GSTM4 reduces detoxification and may sensitize cancer cells to chemotherapeutics[5]