Glutathione S-transferase Mu 5 (GSTM5)

Glutathione S-transferase Mu 5 (GSTM5) is a cytosolic enzyme of the glutathione S-transferase (GST) mu class that catalyzes the conjugation of reduced glutathione to a wide range of electrophilic and hydrophobic substrates, including drugs, carcinogens, and products of oxidative stress[1][2][3]. GSTM5 is involved in cellular detoxification processes and protection from oxidative damage. The mu class GSTs are encoded by highly polymorphic genes, leading to variability in detoxification capacity, which may affect disease susceptibility and drug response in humans[3]. GSTM5 is located on chromosome 1p13.3 and is structurally related to other cytosolic GSTs, sharing the typical GST domain organization. While the biological roles of GSTM5 specifically have not been as extensively documented as those of other GST family members (such as GSTP1 or GSTM1), it is considered part of the cellular defense system against toxic insults and may be relevant to clinical outcomes involving drug metabolism and susceptibility to certain diseases[1][2][3].

Other names

GST class-mu 5GSTM5-5S-(hydroxyalkyl)glutathione lyase M5epididymis secretory sperm binding proteinglutathione S-alkyltransferase M5glutathione S-aralkyltransferase M5glutathione S-aryltransferase M5GTM52.5.1.18

Drugs interacting with GSTM5 are typically detoxified through enzymatic conjugation with glutathione (GSH), increasing water solubility and promoting elimination.