Glutathione S-transferase omega-1 (GSTO1)

Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme belonging to the omega class of glutathione transferases, characterized by a unique active site cysteine and specialized redox functions. It exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities, contributing to cellular redox homeostasis and the glutathione-ascorbate antioxidant cycle[6][2]. GSTO1-1 catalyzes protein (de)glutathionylation, playing a regulatory role in protein function and inflammatory signaling, especially via modulation of TLR4 pathways[1]. GSTO1-1 is implicated in cancer cell proliferation and migration, and its genetic or pharmacological inhibition can attenuate inflammatory responses, making it a potential therapeutic target in inflammatory diseases, cancer, and oxidative stress-related disorders[5][1][4].

Other names

GSTO1-1GSTO1Glutathione transferase omega-1Omega-class glutathione S-transferaseGST omega-1

Covalent and non-covalent inhibition of GSTO1-1 enzymatic activity, Blockade of protein glutathionylation and LPS-stimulated pro-inflammatory signaling[1][4]