Glutathione S-transferase P (GSTP)

Glutathione S-transferase P (GSTP), also known as GST pi or GSTP1, is a member of the glutathione S-transferase (GST) superfamily. These enzymes are primarily involved in phase II detoxification processes, catalyzing the conjugation of reduced glutathione (GSH) to a wide variety of hydrophobic and electrophilic compounds, including environmental toxins, carcinogens, and products of oxidative stress. GSTP is encoded by the polymorphic human gene *GSTP1*. It plays a role in detoxification, redox homeostasis, signal transduction, and apoptosis, and is clinically relevant in cancer susceptibility and drug resistance. It is a potential drug target for overcoming drug resistance and enhancing cancer therapy.

Other names

GST piGSTP1

Inhibition of GSTP activity; silencing of *GSTP1* gene expression