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Glutathione S-transferase P1 (GSTP1)
- Target
- GSTP1
- Molecular classification
- Enzyme, Glutathione S-transferase, Transferase
01
Overview
Glutathione S-transferase P1 (GSTP1) is a member of the glutathione S-transferase (GST) superfamily, specifically belonging to the pi class. GSTs are phase II detoxification enzymes that catalyze the conjugation of reduced glutathione (GSH) to a wide range of hydrophobic and electrophilic compounds, facilitating their detoxification and excretion. GSTP1 is encoded by the polymorphic *GSTP1* gene. It plays a critical role in cellular defense against toxins and oxidative stress and is implicated in drug resistance and cancer.
- Other names
- GST-piGlutathione S-transferase PiGST class-piGST pi
02
Mechanism of action
Catalyzes conjugation of glutathione to electrophilic compounds, detoxifying them. Inhibits JNK, preventing apoptosis. Silencing of GSTP1 expression.
03
Biological functions
DetoxificationXenobiotic metabolismOxidative stress responseApoptosis regulationCatalysis
04
Disease associations
CancerDrug resistanceOxidative stress related diseases
05
Safety considerations
Drug resistance due to increased detoxificationPotential for altered drug metabolism
06
Interacting drugs
Chemotherapy agents
1 more in the full profile.
07
Biomarkers
Elevated GSTP1 expression in tumors
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