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Target intelligence / Profile preview
Glutathione S-transferase pi (GSTP1)
- Target
- GSTP1
- Molecular classification
- Enzyme, Glutathione S-transferase
01
Overview
Glutathione S-transferase pi (GSTP1) is a phase II metabolic enzyme that plays a crucial role in cellular detoxification by catalyzing the conjugation of reduced glutathione to various hydrophobic and electrophilic compounds. It is involved in protecting cells from damage caused by environmental toxins, carcinogens, and products of oxidative stress. GSTP1 also modulates cell signaling pathways and is implicated in cancer development and drug resistance, making it a potential therapeutic target and biomarker.
- Other names
- GSTπGST-Pi
02
Mechanism of action
Inhibition of GSTP1 activity
03
Biological functions
DetoxificationGlutathione conjugationRedox signaling regulationRegulation of apoptosisRegulation of cell survival
04
Disease associations
CancerDrug resistanceOxidative stress-related diseases
05
Safety considerations
Potential for off-target effects with inhibitorsComplexity of GSTP1's role in multiple cellular processes
06
Interacting drugs
Piperlongumine
07
Biomarkers
Cancer diagnosisPrediction of chemoresistance
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