Glutathione S-transferase pi 1 mRNA (GSTP1 mRNA)

Glutathione S-transferase pi 1 (GSTP1) mRNA is the messenger RNA transcript that encodes the GSTP1 enzyme, a key phase II metabolic enzyme involved in the detoxification of electrophilic compounds through conjugation with glutathione [1]. In oncology, GSTP1 mRNA is a critical therapeutic target because its protein product is frequently overexpressed in various malignancies, including pancreatic, colorectal, and lung cancers, where it contributes to chemoresistance by neutralizing platinum-based drugs and other cytotoxics [2][3]. Beyond its catalytic role, the GSTP1 protein also interacts with and inhibits Jun N-terminal kinase (JNK), a pro-apoptotic signaling molecule, thereby promoting tumor cell survival [4]. Therapeutic strategies targeting GSTP1 mRNA primarily involve RNA interference (RNAi), such as the use of small interfering RNAs (siRNAs) like NBF-006, which are designed to bind and trigger the degradation of the transcript [5]. This knockdown approach reduces GSTP1 protein levels, effectively restoring JNK-mediated apoptosis and increasing the sensitivity of cancer cells to standard-of-care chemotherapy [6].

Other names

Glutathione S-transferase P1 mRNAGST class-pi mRNAGST3 mRNAFAEES3 mRNAGlutathione S-transferase pi mRNA

RNA interference (siRNA-mediated mRNA degradation)