Glutathione S-transferase pi 1 pseudogene

Glutathione S-transferase pi 1 pseudogene is a non-protein-coding gene with sequence similarity to the functional glutathione S-transferase pi 1 gene (GSTP1). Pseudogenes typically arise from gene duplication or retrotransposition events and no longer produce a functional protein or enzyme product. Unlike the protein-coding GSTP1 gene—which plays an important role in detoxification and xenobiotic metabolism—the pseudogene lacks enzymatic activity and is not considered a therapeutic or drug discovery target[3]. The current gene nomenclature recognizes several glutathione S-transferase gene subfamilies and pseudogenes in the human genome. GSTP1P or GSTPP refers to this pseudogene related to GSTP1, and it does not encode an active glutathione S-transferase enzyme[3]. There are no known drugs, mechanisms of action, biomarkers, or direct disease associations with this pseudogene, and it is not regarded as a receptor, enzyme, transporter, or classical therapeutic target. If you were seeking information on the active enzyme "glutathione S-transferase pi 1" (canonical name: Glutathione S-transferase pi 1; abbreviation: GSTP1), that is a well-studied detoxification enzyme implicated in drug metabolism and cancer susceptibility[1][2], but this *pseudogene* (ENSG00000283257) is distinct and nonfunctional with respect to protein production[3]. If you need information on the functional enzyme instead, please clarify.

Other names

GSTP1PGSTPPGST pi pseudogene