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Target intelligence / Profile preview
Glutathione S-transferase theta-4 (GSTT4)
- Target
- GSTT4
- Molecular classification
- Pseudogene, Related family: Cytosolic glutathione S-transferases (enzyme superfamily, theta class)
01
Overview
Glutathione S-transferase theta-4 (GSTT4) is part of the theta class of cytosolic glutathione S-transferases, a family of enzymes involved in phase II detoxification by conjugating glutathione to various electrophilic compounds. However, in humans, GSTT4 is a pseudogene (also called glutathione S-transferase theta pseudogene 1, GSTTP1) and does not encode an active enzyme. Functional GST theta enzymes (such as GSTT1 and GSTT2) do exist in humans and contribute to xenobiotic metabolism and cellular protection against oxidative stress, but GSTT4 retains no catalytic or therapeutic relevance due to its pseudogene status
- Other names
- GSTT4Glutathione S-transferase theta-4GST class-theta-4GSTTP1HS322B1AGlutathione S-transferase theta pseudogene 1
02
Mechanism of action
None for GSTT4 (pseudogene).
03
Biological functions
None for GSTT4, as it is a pseudogene in humans and does not produce a functional protein.
04
Disease associations
None directly for GSTT4 (pseudogene)
05
Safety considerations
None identified for GSTT4 specifically, as it is not a drug target or functional protein.
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